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Magnetic Marker Monitoring: imaging gastro-intestinal performance
Magnetic Marker Monitoring is a novel procedure for investigating the transit of a dosage form
(e.g. capsule or tablet) through the gastro-intestinal tract. To achieve this the product is mixed with
a small amount of magnetic black iron oxide (colouring pigment E172 used in pharmaceuticals and
foodstuffs) which can be localized in the GI-tract as a dipole by measuring the magnetic field with
the aid of highly sensitive sensors (superconducting quantum interference devices,
SQUIDS) in a well schielded environment.
This technique, which has been developed by
Prof. Werner Weitschies, University of Greifswald/Germany, together with scientists at the
Physikalisch-Technische Bundesanstalt (PTB, National Metrology Institute), Berlin, is able to
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follow the performance of a dosage form in the stomach and intestines,
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characterize the impact of a formulation on drug absorption,
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localize the delivery of active drug when applied topically to the GI-Tract and
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investigate interactions of meals and food constituents with the formulation.
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These investigations provide useful information for optimizing the formulation of a drug,
e.g. those with modified release or targeted delivery to defined regions of the GI-tract.
All these investigations are carried out in our Clinical Pharmacology Unit at the PTB site, Berlin.
Our intensive cooperation with Professor Werner Weitschies guarantees that the projects are designed,
performed, evaluated and interpreted considering highest international standards and requirements.
Further information can be found in our
PDF-folder "Magnetic Marker Monitoring".
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